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Psoriatic Arthritis — SCE Dermatology MCQ

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HardInflammatory DermatosesPsoriatic ArthritisSCE Dermatology

A patient with severe plaque psoriasis also has relapsing multiple sclerosis. Which targeted treatment class should generally be avoided because it can exacerbate demyelinating disease?

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Correct answer: ATumour-necrosis-factor inhibitors

Tumour-necrosis-factor blockade is avoided in people with demyelinating disease because new or worsening demyelination has been reported. Selection among other targeted therapies should account for psoriasis phenotype, comorbidity, infection risk and current UK commissioning guidance.

Reference: https://www.nice.org.uk/guidance/cg153/chapter/recommendations