Calcinosis Cutis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardConnective Tissue & VasculitisCalcinosis CutisSCE Dermatology

A 55-year-old woman with dermatomyositis develops calcinosis cutis on her elbows. She asks about a topical treatment option. What topical agent has shown promise for calcinosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Topical Sodium thiosulfate (applied to ulcerated calcinotic deposits)

Topical Sodium thiosulfate has shown promise for treating superficial calcinosis cutis, particularly when deposits ulcerate through the skin. Sodium thiosulfate chelates calcium ions, facilitating dissolution of the calcium deposits. It can be applied topically as a 25% aqueous solution or compounded ointment to ulcerated calcinotic areas. Intravenous Sodium thiosulfate is also used for calciphylaxis. Other calcinosis treatments include oral Diltiazem (calcium channel blocker), Minocycline (anti-inflammatory effect on calcium deposits), Colchicine, Aluminium hydroxide (phosphate binder), and surgical excision of symptomatic deposits. Calcinosis cutis in DM is one of the most treatment-resistant complications.

Reference: BAD 2016 DM; BJD Calcinosis Review