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Dermatitis Herpetiformis — SCE Dermatology MCQ

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HardBlistering DiseasesDermatitis HerpetiformisSCE Dermatology

Dermatitis herpetiformis is confirmed and dapsone is being considered for rapid symptom control. Which baseline test is specifically important before treatment?

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Correct answer: C — Glucose-6-phosphate dehydrogenase activity

Dapsone can cause dose-related haemolysis and methaemoglobinaemia, with greater risk in glucose-6-phosphate dehydrogenase deficiency. Baseline G6PD, full blood count, liver and renal assessment and subsequent monitoring are required; a strict gluten-free diet treats the underlying disease.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines