Psoriasis — SCE Dermatology MCQ

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EasyDermatopharmacologyPsoriasisSCE Dermatology

A 40-year-old man with psoriasis has just completed his first dose of Secukinumab. He asks about the dosing schedule. What is the standard Secukinumab dosing regimen for psoriasis?

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Correct answer: D — 300 mg at weeks 0, 1, 2, 3, 4 (loading), then 300 mg every 4 weeks (maintenance)

Secukinumab (anti-IL-17A) dosing for moderate-to-severe plaque psoriasis: loading phase of 300 mg SC at weeks 0, 1, 2, 3, and 4 (weekly for 5 weeks), followed by maintenance phase of 300 mg SC every 4 weeks. This front-loaded dosing achieves rapid PASI improvement. Some patients may receive 150 mg (particularly if body weight <90 kg). For psoriatic arthritis, the dose may differ. Response should be assessed at 12-16 weeks using PASI and DLQI. The loading phase distinguishes Secukinumab from some other biologics and contributes to its rapid onset of action. Injection site reactions and upper respiratory tract infections are common mild adverse effects.

Reference: NICE TA350 Secukinumab; BAD 2020; BNF