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Urticarial Vasculitis — SCE Dermatology MCQ

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HardConnective Tissue & VasculitisUrticarial VasculitisSCE Dermatology

A patient has painful wheals lasting 36 hours and leaving purpura. Which investigation most directly distinguishes urticarial vasculitis from chronic spontaneous urticaria?

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Correct answer: A — Histology of an early active wheal

An early active lesion can demonstrate leukocytoclastic vasculitis, vascular-wall injury and erythrocyte extravasation. Complement, renal testing and autoimmune investigations assess subtype and systemic involvement, but histology establishes that the wheal represents vasculitis.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines