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Bullous SLE — SCE Dermatology MCQ

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HardBlistering DiseasesBullous SLESCE Dermatology

A patient with systemic lupus develops a neutrophil-rich subepidermal blistering eruption. Direct immunofluorescence shows granular IgG, IgA, IgM and C3 along the basement membrane. What is the diagnosis?

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Correct answer: D — Bullous systemic lupus erythematosus

Bullous systemic lupus erythematosus combines a rapid neutrophilic subepidermal eruption with serological or clinical lupus and a lupus-band immunofluorescence pattern. Type VII collagen antibodies may occur, but the clinicopathological setting and often brisk dapsone response distinguish it from mechanobullous epidermolysis bullosa acquisita.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines