A child with severe early atopic eczema has a heterozygous loss-of-function FLG variant. Which biochemical consequence most directly explains

Question

A child with severe early atopic eczema has a heterozygous loss-of-function FLG variant. Which biochemical consequence most directly explains increased transepidermal water loss?

Accepted Answer

Reduced hygroscopic amino acids within natural moisturising factor

Answer

Reduced melanosome transfer from melanocytes to suprabasal keratinocytes

Answer

Reduced dermal glycosaminoglycan synthesis by papillary fibroblasts

Answer

Reduced type VII collagen assembly beneath the epidermal basement membrane

Answer

Reduced lamellar-body ceramide secretion caused by absent sebaceous filaggrin

Atopic Eczema — SCE Dermatology MCQ

A child with severe early atopic eczema has a heterozygous loss-of-function FLG variant. Which biochemical consequence most directly explains increased transepidermal water loss?