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Keratoacanthoma — SCE Dermatology MCQ

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HardSkin CancerKeratoacanthomaSCE Dermatology

A rapidly growing crateriform keratinising nodule could represent keratoacanthoma or well-differentiated squamous cell carcinoma. Why is complete architectural sampling preferred?

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Correct answer: E — The lateral lips and deep interface are diagnostically important

The distinction relies heavily on overall symmetry, crateriform architecture, lateral epidermal lips and the relationship of the deep tumour front to the lesion margins. A small partial biopsy may show only a well-differentiated squamous proliferation and cannot reliably establish benign behaviour.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines