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Melanoma — SCE Dermatology MCQ

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HardDermatological SurgeryMelanomaSCE Dermatology

A scar-like scalp plaque is composed of infiltrative spindle cells in a collagenous stroma. The cells are SOX10 and S100 positive but Melan-A negative, and there is neurotropism. What is the diagnosis?

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Correct answer: A — Desmoplastic melanoma

Desmoplastic melanoma often resembles a scar and is composed of spindle melanocytes in dense collagen. Diffuse S100 and SOX10 expression with absent or weak conventional melanocytic markers, together with neurotropism, is characteristic and explains the high local-recurrence risk.

Reference: https://www.nice.org.uk/guidance/ng14/chapter/recommendations