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Dermatomyositis — SCE Dermatology MCQ

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HardConnective Tissue & VasculitisDermatomyositisSCE Dermatology

A patient with inflammatory myopathy has hyperkeratotic fissured lateral fingers and papules on the palmar aspects of the metacarpophalangeal joints. Interstitial lung disease is present. Which antibody group is most relevant?

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Correct answer: E — Anti-aminoacyl-tRNA synthetase antibodies

Mechanic’s hands and inverse Gottron-type palmar papules with myositis and interstitial lung disease suggest antisynthetase syndrome. Anti-Jo-1 is the commonest member, but PL-7, PL-12 and other aminoacyl-tRNA synthetase antibodies can produce prominent lung disease.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines