Drug-Induced Linear IgA — SCE Dermatology MCQ

Correct answer: B — Stop Vancomycin — it is the most common drug cause of linear IgA disease; the eruption should resolve within weeks

Vancomycin is the most common drug cause of linear IgA bullous dermatosis in adults. Drug-induced linear IgA disease typically develops 1-2 weeks after drug initiation and resolves within days to weeks of drug withdrawal. Other causative drugs include non-steroidal anti-inflammatory drugs, Captopril, Lithium, and antibiotics (Cephalosporins, Trimethoprim). If the drug cannot be stopped or if symptoms are severe, Dapsone provides rapid symptomatic relief. The clinical and histological features are identical to idiopathic linear IgA disease. Drug causation should always be considered in adult-onset linear IgA disease.

Reference: BAD 2019 Linear IgA Guidelines