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Psoriasis — SCE Dermatology MCQ

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EasyDermatopharmacologyPsoriasisSCE Dermatology

A 55-year-old woman has chronic plaque psoriasis and has been prescribed a topical Vitamin D analogue (Calcipotriol). What is the maximum recommended weekly dose of Calcipotriol to avoid hypercalcaemia?

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Correct answer: E — 100 g per week

Topical Calcipotriol (a Vitamin D3 analogue) should not exceed 100 g per week to minimise the risk of hypercalcaemia from systemic absorption. When used in combination with Betamethasone (Dovobet/Enstilar), the same 100 g/week maximum applies. Patients should be counselled about this limit and signs of hypercalcaemia (nausea, thirst, polyuria, constipation). Serum calcium monitoring may be considered in patients using high volumes or those with renal impairment. Calcipotriol works by binding to Vitamin D receptors in keratinocytes, inhibiting proliferation and promoting differentiation, with immunomodulatory effects.

Reference: BAD 2020 Psoriasis Guidelines; BNF