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CTCL — SCE Dermatology MCQ

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HardSkin CancerCTCLSCE Dermatology

T-cell receptor analysis identifies the same dominant clone in two anatomically separate, clinically suspicious patches, while reactive controls are polyclonal. How should this result be interpreted?

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Correct answer: B — It supports cutaneous T-cell lymphoma in clinicopathological context

Finding an identical dominant T-cell clone in separate lesions is more supportive of cutaneous T-cell lymphoma than clonality in one sample. It remains supportive rather than standalone evidence because restricted clones can occasionally occur in inflammatory dermatoses.

Reference: https://academic.oup.com/bjd/article/180/3/496/6749857