Recurrent Cellulitis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCutaneous InfectionRecurrent CellulitisSCE Dermatology

A 58-year-old man has recurrent cellulitis of his left leg (4 episodes in the past year). He has chronic lymphoedema. According to the PATCH trial evidence, what prophylactic antibiotic reduces recurrence?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Prophylactic Penicillin V 250 mg BD

The PATCH trial (Prophylactic Antibiotics for the Treatment of Cellulitis at Home) demonstrated that prophylactic Penicillin V (Phenoxymethylpenicillin) 250 mg twice daily significantly reduces recurrence of lower limb cellulitis in patients with recurrent episodes. BAD and NICE guidelines recommend considering prophylactic Penicillin V for patients with ≥2 episodes of cellulitis in the same location within 12 months. Other important measures include optimising treatment of predisposing factors (lymphoedema management, tinea pedis treatment, skin care/emollients to maintain skin barrier integrity).

Reference: PATCH Trial BJD 2013; NICE NG141 2019; BAD