Acne Vulgaris — SCE Dermatology MCQ
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Correct answer: E — 120-150 mg/kg total
The target cumulative dose of Isotretinoin is 120-150 mg/kg for a course of treatment. This typically equates to 5-7 months of treatment at standard dosing (0.5-1 mg/kg/day). Starting at lower doses (0.5 mg/kg/day) and increasing reduces initial flare risk and side effects. Reaching the target cumulative dose minimises relapse risk. Approximately 60-80% of patients achieve long-term remission after one course. A second course may be needed if relapse occurs (usually at least 8 weeks after completing the first course to assess full benefit). Lower cumulative doses are associated with higher relapse rates.
Reference: BAD 2023 Acne Guidelines; BNF