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Erythroderma — SCE Dermatology MCQ

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HardInflammatory DermatosesErythrodermaSCE Dermatology

A patient with erythroderma has a blood T-cell clone and an aberrant CD4-positive population. Which additional finding satisfies a recognised high blood-tumour-burden criterion for Sézary syndrome staging?

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Correct answer: D — At least 1,000 Sézary cells per microlitre

B2 blood involvement requires a high absolute burden of phenotypically abnormal clonal T cells; an absolute Sézary-cell count of at least 1,000 per microlitre is a recognised criterion. Clonality or modest immunophenotypic abnormalities alone do not establish high blood burden.

Reference: https://academic.oup.com/bjd/article/180/3/496/6749857