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Paraneoplastic Pemphigus — SCE Dermatology MCQ

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HardBlistering DiseasesParaneoplastic PemphigusSCE Dermatology

A patient with non-Hodgkin lymphoma develops severe refractory stomatitis, polymorphous skin lesions and conjunctival involvement. Histology combines suprabasal acantholysis with interface dermatitis. Which diagnosis is most likely?

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Correct answer: A — Paraneoplastic pemphigus

Paraneoplastic pemphigus, also termed paraneoplastic autoimmune multiorgan syndrome, produces severe stomatitis with polymorphous mucocutaneous disease in association with lymphoproliferative neoplasia. Acantholytic and interface patterns may coexist, and bronchiolitis obliterans is an important complication.

Reference: https://academic.oup.com/bjd/article/177/5/1170/6749752