Dermatomyositis — SCE Dermatology MCQ

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HardConnective Tissue & VasculitisDermatomyositisSCE Dermatology

A 30-year-old woman is diagnosed with dermatomyositis. She has the characteristic heliotrope rash, Gottron papules, proximal muscle weakness, and raised CK. Which myositis-specific antibody is associated with the highest risk of malignancy?

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Correct answer: E — Anti-TIF1γ myositis antibody

The best answer is “Anti-TIF1γ myositis antibody”. Dermatomyositis combines characteristic cutaneous signs with inflammatory myopathy; antibody phenotype helps estimate malignancy and interstitial-lung-disease risk but must be interpreted with the clinical picture. The alternatives “Anti-Mi-2 antibody”, “Anti-MDA5 antibody”, “Anti-Jo-1 antibody”, “Anti-SRP antibody” are clinically adjacent possibilities, but they do not fit the defining morphology, distribution, histopathology, risk signal or management sequence in this stem.

Reference: BAD dermatomyositis information: https://www.bad.org.uk/pils/dermatomyositis