Graham-Little Syndrome — SCE Dermatology MCQ

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HardHair DisordersGraham-Little SyndromeSCE Dermatology

A 46-year-old woman presents with scarring alopecia. She has associated keratosis pilaris-like papules on her upper arms and non-scarring alopecia of her axillae and pubic area. She has lost her lateral eyebrows. What is the most likely diagnosis?

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Correct answer: B — Graham-Little-Piccardi-Lasseur syndrome

Graham-Little-Piccardi-Lasseur (GLPL) syndrome is a rare variant of lichen planopilaris characterised by the triad of: (1) cicatricial (scarring) alopecia of the scalp, (2) keratosis pilaris-like follicular papules on the trunk/limbs, and (3) non-scarring alopecia of the axillae and/or pubic area. It predominantly affects women. The association of scarring scalp alopecia with non-scarring body hair loss and keratotic follicular papules is the key diagnostic triad. Treatment is as for lichen planopilaris — topical/intralesional corticosteroids, Hydroxychloroquine, and Finasteride/Dutasteride.

Reference: BAD 2012 Cicatricial Alopecia Guidelines