skip to main content

Langerhans Cell Histiocytosis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardPaediatric DermatologyLangerhans Cell HistiocytosisSCE Dermatology

An infant has a haemorrhagic, crusted seborrhoeic-like eruption of the scalp and flexures with hepatosplenomegaly. Which diagnosis must be excluded urgently?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Langerhans cell histiocytosis

Langerhans cell histiocytosis can mimic infantile seborrhoeic dermatitis but haemorrhagic crusting and systemic signs are red flags. Skin biopsy with CD1a and langerin expression supports the diagnosis and should be followed by multisystem staging.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines