skip to main content

Pemphigoid Gestationis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardBlistering DiseasesPemphigoid GestationisSCE Dermatology

A 60-year-old man with pemphigoid gestationis (herpes gestationis) — Actually this is incorrect as this affects women. Let me correct. A 35-year-old woman in the third trimester of pregnancy develops intensely pruritic urticarial plaques and vesicles around the umbilicus spreading to her trunk and limbs. DIF shows linear C3 at the basement membrane zone. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Pemphigoid gestationis

Pemphigoid gestationis (PG, formerly herpes gestationis) is a rare autoimmune blistering disease of pregnancy caused by anti-BP180 (NC16A domain) IgG antibodies. It typically presents in the second or third trimester with intensely pruritic urticarial plaques and vesicles, often starting periumbilically. Linear C3 at the BMZ on DIF is the hallmark finding. IgG may also be present. PG carries risks of prematurity and small-for-gestational-age infants. Treatment includes potent topical corticosteroids and systemic Prednisolone. It may recur in subsequent pregnancies and with oral contraceptive use. PEEP (polymorphic eruption) typically spares the periumbilical area.

Reference: BAD 2017 Pemphigoid Gestationis Guidelines