Pemphigus Foliaceus — SCE Dermatology MCQ

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HardBlistering DiseasesPemphigus FoliaceusSCE Dermatology

A pustular eruption has subcorneal neutrophils and intercellular IgA predominantly in the upper epidermis. Which autoantigen is most characteristic of the subcorneal pustular dermatosis type of IgA pemphigus?

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Correct answer: A — Desmocollin-1

The subcorneal pustular dermatosis type of IgA pemphigus is associated with IgA autoantibodies against desmocollin-1. The intraepidermal neutrophilic type has a less consistent antigenic target and may stain throughout the epidermis.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines