skip to main content

Syphilis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCutaneous InfectionSyphilisSCE Dermatology

A 30-year-old woman presents with a symmetrical papulosquamous eruption on her palms and soles, along with mucous patches on her oral mucosa, condylomata lata in the anogenital region, and diffuse non-scarring alopecia ('moth-eaten'). Syphilis serology is positive. What stage of syphilis does this represent?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Secondary syphilis

Secondary syphilis presents 6-12 weeks after the primary chancre with a widespread papulosquamous rash (classically involving palms and soles), mucous patches (painless oral erosions), condylomata lata (moist papules in intertriginous areas), and moth-eaten alopecia (diffuse non-scarring). It is highly infectious. Both non-treponemal (RPR/VDRL) and treponemal (TPHA/FTA-Abs) tests are positive. Treatment is IM Benzathine penicillin G 2.4 MU single dose. Secondary syphilis is the great mimic and must be considered in any widespread papulosquamous eruption.

Reference: BASHH 2015 UK National Guidelines on Syphilis; BAD