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Paget Disease of Breast — SCE Dermatology MCQ

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HardSkin CancerPaget Disease of BreastSCE Dermatology

A woman has unilateral nipple erosion. Biopsy shows a compact papillary proliferation arising from lactiferous ducts, with a dual epithelial and myoepithelial layer and no Paget cells. What is the diagnosis?

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Correct answer: B — Nipple adenoma

Nipple adenoma is a benign papillary adenomatous proliferation of lactiferous ducts that can cause erosion and mimic Paget disease clinically. Preservation of a myoepithelial layer and absence of intraepidermal Paget cells support the diagnosis, although complete clinicopathological assessment is required.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines