skip to main content

Psoriasis Prognosis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardInflammatory DermatosesPsoriasis PrognosisSCE Dermatology

A patient receiving a tumour-necrosis-factor inhibitor for inflammatory bowel disease develops new palmoplantar pustules and scalp plaques despite control of the bowel disease. What is the most likely explanation?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Paradoxical psoriasis induced by tumour-necrosis-factor blockade

Tumour-necrosis-factor inhibitors can paradoxically induce or worsen psoriasiform disease, often with scalp or palmoplantar pustular involvement. Management depends on severity and control of the underlying disease, ranging from topical treatment while continuing therapy to switching drug class.

Reference: https://www.nice.org.uk/guidance/cg153/chapter/recommendations