Calcipotriol Max Dose — SCE Dermatology MCQ
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Correct answer: A — 100 g per week (to avoid hypercalcaemia from excessive Vitamin D analogue absorption)
Calcipotriol (a Vitamin D3 analogue) has a maximum recommended weekly application of 100 g to avoid the risk of hypercalcaemia from systemic absorption. At excessive doses, Vitamin D analogue absorption can cause: hypercalcaemia, hypercalciuria, and suppression of parathyroid hormone. Serum calcium monitoring is recommended if applying close to the maximum amount. The 100 g/week limit also applies to the Calcipotriol/Betamethasone combination products. In practice, patients applying to limited body areas rarely approach this threshold, but those with widespread psoriasis using Calcipotriol to large BSA may exceed it. Awareness of this limit is important for prescribers and pharmacists dispensing large quantities.
Reference: BAD 2020 Psoriasis; BNF SmPC