skip to main content

Anti-Mi-2 Prognosis — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardConnective Tissue & VasculitisAnti-Mi-2 PrognosisSCE Dermatology

A 50-year-old man has been diagnosed with dermatomyositis. His myositis-specific antibody panel shows positive anti-Mi-2. What does anti-Mi-2 positivity indicate?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Classic dermatomyositis phenotype with generally favourable treatment response

The best answer is “Classic dermatomyositis phenotype with generally favourable treatment response”. Dermatomyositis combines characteristic cutaneous signs with inflammatory myopathy; antibody phenotype helps estimate malignancy and interstitial-lung-disease risk but must be interpreted with the clinical picture. The alternatives “High cancer risk, after clinicopathological correlation”, “Poor prognosis, after specialist assessment, when the full phenotype supports it”, “Amyopathic disease, when the full phenotype supports it”, “High ILD risk, within an appropriate UK pathway” are clinically adjacent possibilities, but they do not fit the defining morphology, distribution, histopathology, risk signal or management sequence in this stem.

Reference: BAD dermatomyositis information: https://www.bad.org.uk/pils/dermatomyositis