Psoriasis — SCE Dermatology MCQ

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EasyDermatopharmacologyPsoriasisSCE Dermatology

A 45-year-old woman with severe chronic plaque psoriasis is being considered for Secukinumab. Which of the following is a mandatory pre-treatment screening requirement?

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Correct answer: A — Hepatitis B and C serology

Before starting any biologic therapy for psoriasis, BAD guidelines mandate screening for latent tuberculosis (interferon-gamma release assay or Mantoux test), hepatitis B and C serology, HIV testing, and assessment for active/latent infections. Hepatitis B screening is critical because IL-17 inhibitors and other biologics can cause reactivation of latent hepatitis B. ANA, complement, immunoglobulin levels and bone marrow biopsy are not routine pre-biologic screening tests.

Reference: BAD 2020 Guidelines for biologic therapy for psoriasis