skip to main content

Extramammary Paget Disease — SCE Dermatology MCQ

Instant feedback + full explanation. One question, done properly.

HardGenital DermatologyExtramammary Paget DiseaseSCE Dermatology

Perianal extramammary Paget cells are CK7 negative, CK20 and CDX2 positive, with strong nuclear SATB2 expression. What does this immunophenotype most strongly suggest?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Secondary epidermotropic spread from colorectal adenocarcinoma

CK20, CDX2 and SATB2 expression with absent CK7 supports intestinal differentiation and should prompt investigation for an underlying colorectal or anal adenocarcinoma. Primary cutaneous extramammary Paget disease is more often CK7 positive and lacks a convincing intestinal profile.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines