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Drugs Increasing Urate — SCE Rheumatology MCQ

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ModerateCrystal ArthropathyDrugs Increasing UrateSCE Rheumatology

A 60-year-old man with gout and heart failure asks whether his medications affect urate. His current medications are Furosemide Aspirin 75mg and Atorvastatin. Which increase urate?

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Correct answer: B — Both Furosemide (loop diuretic reduces renal urate excretion) and low-dose Aspirin (inhibits urate secretion at doses <2g/day) increase serum urate levels

Furosemide: reduces renal urate excretion via volume contraction and tubular competition. Low-dose Aspirin (<2g): inhibits renal urate secretion (paradoxically high-dose >3g is uricosuric). Atorvastatin: no significant effect. Consider Losartan (uricosuric) for hypertension if applicable.

Reference: BSR 2017 gout