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Multi-Target LN Therapy — SCE Rheumatology MCQ

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HardSLE & Antiphospholipid SyndromeMulti-Target LN TherapySCE Rheumatology

A 45-year-old woman with SLE and LN on MMF asks about a multi-target therapy approach. What does multi-target therapy mean in LN?

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Correct answer: C — Combining a calcineurin inhibitor (Tacrolimus or Voclosporin) with Mycophenolate and low-dose steroids targeting multiple pathogenic mechanisms simultaneously for superior renal response

Multi-target LN: CNI (Tacrolimus/Voclosporin) plus MMF plus low-dose steroids. Targets: B-cell activation (MMF) podocyte stabilisation and T-cell inhibition (CNI). AURORA-1 (Voclosporin) and Chinese multi-target studies showed superior complete response rates.

Reference: EULAR 2023 SLE; Rovin BH 2021 AURORA