Allopurinol Uptitration Step — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

EasyCrystal ArthropathyAllopurinol Uptitration StepSCE Rheumatology

A 55-year-old man with gout targets serum urate <360. His current urate is 420 on Allopurinol 200mg. What is the next step?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Increase Allopurinol by 100mg with monthly urate checks continuing uptitration until target achieved

Treat-to-target: monthly uptitration by 100mg increments guided by serum urate. Most common failure reason is under-dosing. Maximum 900mg daily. Continue until target <360 (or <300 for tophaceous) achieved.

Reference: BSR 2017; NICE NG219