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Two Approved Biologics SLE — SCE Rheumatology MCQ

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ModerateSLE & Antiphospholipid SyndromeTwo Approved Biologics SLESCE Rheumatology

A 48-year-old woman with SLE has persistent active disease despite HCQ and MTX. Her SLEDAI is 10. She is on Prednisolone 15mg. EULAR 2023 recommends adding a biologic. Which two biologics are approved for non-renal SLE?

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Correct answer: E — Belimumab (anti-BLyS) and Anifrolumab (anti-IFNAR1) without requiring prior csDMARD failure

EULAR 2023: Belimumab and Anifrolumab for moderate-severe non-renal SLE. Prior csDMARD failure NOT required. Both facilitate steroid reduction. Belimumab also approved for LN. Rituximab used off-label for refractory SLE.

Reference: EULAR 2023 SLE