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SRC ACE Inhibitor Treatment — SCE Rheumatology MCQ

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HardSystemic SclerosisSRC ACE Inhibitor TreatmentSCE Rheumatology

A patient with systemic sclerosis develops a newly black fingertip, severe rest pain and absent digital Doppler flow despite maximal tolerated oral vasodilators. There is no established sepsis. What is the appropriate next step?

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Correct answer: ATreat as critical digital ischaemia and arrange urgent IV iloprost-based rescue assessment

Explanation lettering: C = shown as A · D = shown as C · E = shown as D · A = shown as E

C is correct. BSR classifies new tissue necrosis or critical digital ischaemia as an emergency requiring urgent assessment, ideally within 48 hours; intravenous prostanoid and combined specialist vascular strategies may be required. A delays limb-saving care. B may increase renal-crisis risk and does not target the usual vasculopathy. D overstates bosentan, whose clearest role is preventing new ulcers. E abandons assessment for reversible macrovascular disease and rescue procedures.

Reference: BSR systemic sclerosis guideline 2024: https://academic.oup.com/rheumatology/article/63/11/2956/7750184