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HCQ Weight Dosing Calculation — SCE Rheumatology MCQ

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HardSLE & Antiphospholipid SyndromeHCQ Weight Dosing CalculationSCE Rheumatology

A patient with SLE weighs 55 kg and is prescribed hydroxychloroquine. How should the retinal-toxicity dose recommendation be applied in practice?

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Correct answer: E — Keep the average dose at or below 5 mg/kg/day actual body weight

The recommended ceiling is based on average daily dose using actual body weight. Because tablets may not permit the exact mathematical dose, clinicians can use a practical lower dose or an alternating schedule. Renal impairment, duration and tamoxifen further increase retinal risk.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions