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Renal Biopsy Importance LN — SCE Rheumatology MCQ

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HardSLE & Antiphospholipid SyndromeRenal Biopsy Importance LNSCE Rheumatology

A patient with SLE develops persistent proteinuria and active urinary sediment consistent with lupus nephritis. Why is kidney biopsy important?

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Correct answer: A — It classifies histological activity and chronicity to guide treatment and prognosis

The best answer is “It classifies histological activity and chronicity to guide treatment and prognosis”. Clinical and laboratory findings do not reliably define lupus-nephritis class or distinguish active reversible inflammation from chronic damage. Biopsy may be indicated despite preserved creatinine, is not an ANA test, can materially change therapy, and complements rather than replaces quantitative urine monitoring.

Reference: EULAR lupus nephritis recommendations: https://ard.bmj.com/content/79/6/713