A patient with active psoriatic arthritis has recurrent anterior uveitis and moderately active Crohn disease despite methotrexate. Axial and

Question

A patient with active psoriatic arthritis has recurrent anterior uveitis and moderately active Crohn disease despite methotrexate. Axial and peripheral musculoskeletal activity both require a biologic. Which mechanism best covers the complete phenotype?

Accepted Answer

A monoclonal TNF inhibitor such as adalimumab or infliximab

Answer

An IL-17 inhibitor because it reliably treats active Crohn disease

Answer

Etanercept because soluble-receptor TNF blockade is preferred for recurrent uveitis

Answer

Abatacept for arthritis combined with mesalazine for Crohn disease and topical psoriasis treatment

Answer

Abatacept because it is first choice for axial PsA and bowel inflammation

Heberden Bouchard Nodes — SCE Rheumatology MCQ

A patient with active psoriatic arthritis has recurrent anterior uveitis and moderately active Crohn disease despite methotrexate. Axial and peripheral musculoskeletal activity both require a biologic. Which mechanism best covers the complete phenotype?