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APS Anticoagulation Duration — SCE Rheumatology MCQ

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HardSLE & Antiphospholipid SyndromeAPS Anticoagulation DurationSCE Rheumatology

A patient with triple-positive APS develops an arterial stroke while taking rivaroxaban. What long-term antithrombotic strategy is preferred?

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Correct answer: C — Switch to a vitamin K antagonist under specialist care

Direct oral anticoagulants are associated with excess recurrent events in high-risk triple-positive APS, especially arterial thrombosis. A vitamin K antagonist is preferred, with intensity and possible antiplatelet use individualised by an APS specialist.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions