First-Line SpA Treatment — SCE Rheumatology MCQ

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EasySpondyloarthropathyFirst-Line SpA TreatmentSCE Rheumatology

A 42-year-old man with axSpA starts treatment. What is BSR 2025 first-line pharmacological therapy?

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Correct answer: C — Two full-dose NSAID trials

BSR 2025/EULAR-ASAS 2022: NSAIDs first-line. At least 2 at full dose 2-4 weeks each. csDMARDs NO efficacy for axial disease. Steroids very limited role. NSAID failure required before biologic.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions