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RA Work Disability — SCE Rheumatology MCQ

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HardRheumatoid ArthritisRA Work DisabilitySCE Rheumatology

A patient with systemic sclerosis has recurrent bloating, steatorrhoea, weight loss and vitamin deficiencies; obstruction and pancreatic insufficiency are excluded. Symptoms repeatedly improve with antibiotics. What is the preferred management of symptomatic small-intestinal bacterial overgrowth?

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Correct answer: EUse rotating intermittent antibiotic courses for recurrent disease

Explanation lettering: E = shown as A · D = shown as B · A = shown as C · B = shown as D · C = shown as E

C is correct. BSR recommends intermittent broad-spectrum oral antibiotics, such as ciprofloxacin, for symptomatic SSc small-intestinal bacterial overgrowth; rotational regimens may help recurrent disease and rifaximin is an option when refractory. The underlying dysmotility makes recurrence common, so one response does not prove cure. Immunosuppression does not reverse established enteric fibrosis, surgery is avoided unless essential, and parenteral nutrition is reserved for severe malnutrition refractory to enteral support rather than used before antimicrobial treatment.

Reference: BSR 2024 systemic-sclerosis guideline executive summary: https://academic.oup.com/rheumatology/article/63/11/2948/7750185