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Infliximab Pre-Medication — SCE Rheumatology MCQ

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EasyRheumatology PharmacologyInfliximab Pre-MedicationSCE Rheumatology

A 42-year-old woman with RA on Infliximab requires pre-medication. What is typically given?

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Correct answer: A — Paracetamol antihistamine and sometimes low-dose IV Hydrocortisone to reduce infusion reactions

Infusion reactions 5-10%. Standard: Paracetamol 1g antihistamine (Chlorphenamine) and often IV Hydrocortisone 100-200mg. Slower rates reduce risk. Concomitant MTX reduces immunogenicity.

Reference: BSR 2019 biologic safety; BNF Infliximab