ESSDAI Sjogren Activity — SCE Rheumatology MCQ

Correct answer: D — Weighted physician-assessed systemic disease activity across 12 organ-specific domains

ESSDAI is a weighted, physician-assessed measure of current systemic disease activity in Sjögren disease. It covers 12 domains: constitutional, lymphadenopathic, glandular, articular, cutaneous, pulmonary, renal, muscular, peripheral nervous system, central nervous system, haematological and biological. Therefore, D is correct. Option C describes ESSPRI, the patient-reported index covering dryness, fatigue and pain. ESSDAI is an activity rather than accumulated-damage index, so C is incorrect. Schirmer testing and unstimulated salivary flow assess glandular function and contribute to classification or clinical evaluation but are not the ESSDAI construct, excluding D. Although some ESSDAI features may be associated with lymphoma risk, the index is not a lymphoma prediction model, excluding E.

Reference: EULAR Outcome Measures Library. Sjögren's syndrome disease activity index (ESSDAI). https://oml.eular.org/oml_search_results_details.cfm?action=All+information&id=494&lightbox%5Bheight%5D=90p&lightbox%5Biframe%5D=true&lightbox%5Bwidth%5D=90p