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Sjogren Fatigue Management — SCE Rheumatology MCQ

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HardConnective Tissue DiseaseSjogren Fatigue ManagementSCE Rheumatology

A patient with Sjögren disease has severe fatigue but stable ESSDAI, normal blood count and thyroid tests, restorative sleep apnoea treatment and no lymphoma warning features. Which intervention has the clearest guideline support?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Prescribe a graded aerobic and resistance exercise programme

Explanation lettering: D = shown as A · A = shown as C · E = shown as D · C = shown as E

A is correct. BSR recommends a holistic review and states that exercise is safe and potentially beneficial for Sjögren fatigue, although no single exercise type is proven superior. Rituximab, stimulants, glucocorticoid escalation and supratherapeutic hydroxychloroquine are not evidence-based fatigue treatments in the absence of another indication.

Reference: 2024 British Society for Rheumatology Sjögren disease guideline. https://academic.oup.com/rheumatology/article/64/2/409/7645909