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Sjogren LIP — SCE Rheumatology MCQ

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HardConnective Tissue DiseaseSjogren LIPSCE Rheumatology

A woman with primary Sjögren disease develops dry cough and exertional dyspnoea. HRCT shows lower-zone ground-glass change with thin-walled cysts and a lymphoid interstitial pattern. What pulmonary diagnosis is most likely?

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Correct answer: A — Lymphocytic interstitial pneumonia associated with Sjögren disease

The best answer is “Lymphocytic interstitial pneumonia associated with Sjögren disease”. Sjögren disease can cause lymphoid interstitial lung disease, and ground-glass change with thin-walled cysts supports LIP. Asthma, embolism, rheumatoid UIP and drug pneumonitis do not match the characteristic clinical and CT combination. Pulmonary function testing and specialist respiratory assessment then help quantify severity, identify complications and guide treatment rather than assuming that every Sjögren lung presentation has the same pattern.

Reference: BSR Sjögren disease guideline: https://academic.oup.com/rheumatology/article/64/2/409/7645909