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Anti-SRP IMNM Treatment — SCE Rheumatology MCQ

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HardMyositisAnti-SRP IMNM TreatmentSCE Rheumatology

A patient with anti-HMGCR immune-mediated necrotising myopathy remains profoundly weak with CK 12,000 IU/L after stopping statin treatment. Which additional therapy has particular evidence in this phenotype?

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Correct answer: EIntravenous immunoglobulin as part of combination immunotherapy

Anti-HMGCR myopathy usually persists after statin withdrawal and requires immunotherapy. IVIg can be especially effective and is commonly combined with glucocorticoid-sparing treatment according to severity. Early rehabilitation is important but does not replace immune treatment.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions