skip to main content

Biologic Infection Risk Factors — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

HardRheumatoid ArthritisBiologic Infection Risk FactorsSCE Rheumatology

Which patient factor most clearly increases serious-infection risk during biological treatment for rheumatoid arthritis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Concurrent glucocorticoid exposure and previous serious infection

The best answer is “Concurrent glucocorticoid exposure and previous serious infection”. Serious-infection risk during biological therapy rises with glucocorticoid exposure, previous infection, older age, comorbidity and high disease activity. A young healthy patient with controlled disease has lower baseline risk, while serostatus, prior hydroxychloroquine alone and a remote mechanical injury are not comparable predictors.

Reference: BSR biologic DMARD safety guideline: https://academic.oup.com/rheumatology/article/58/2/e3/5076446