A 55-year-old woman has recently diagnosed rheumatoid arthritis. Her anti-CCP concentration is 250 U/mL (laboratory upper limit of normal 20 U/mL),

Question

A 55-year-old woman has recently diagnosed rheumatoid arthritis. Her anti-CCP concentration is 250 U/mL (laboratory upper limit of normal 20 U/mL), and rheumatoid factor is positive. Which statement best reflects the prognostic significance of this result in current UK practice?

Accepted Answer

Anti-CCP positivity predicts greater radiographic progression; it supports a remission target but alone does not dictate a specific DMARD regimen.

Answer

Rheumatoid factor is the only serological marker associated with radiographic progression in rheumatoid arthritis.

Answer

Serial anti-CCP titres reliably reflect inflammatory activity and should guide escalation of DMARD treatment.

Answer

Anti-CCP supports diagnosis, but its presence provides no prognostic information once rheumatoid arthritis is diagnosed.

Answer

Low-titre anti-CCP predicts more radiographic progression than high-titre anti-CCP in otherwise comparable patients.

Anti-CCP Prognostic Value — SCE Rheumatology MCQ

A 55-year-old woman has recently diagnosed rheumatoid arthritis. Her anti-CCP concentration is 250 U/mL (laboratory upper limit of normal 20 U/mL), and rheumatoid factor is positive. Which statement best reflects the prognostic significance of this result in current UK practice?