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Ultrasound in PMR Criteria — SCE Rheumatology MCQ

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HardVasculitisUltrasound in PMR CriteriaSCE Rheumatology

A 76-year-old on furosemide is due for Aclasta. Cockcroft–Gault CrCl is 58 mL/min and calcium is normal, but she is clinically volume depleted after gastroenteritis. Which administration plan best follows the SmPC?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Rehydrate first, retain the 5 mg dose, and infuse over no less than 15 minutes

Explanation lettering: D = shown as A · E = shown as B · B = shown as C · C = shown as D · A = shown as E

A is correct. With CrCl at least 35 mL/min, no Aclasta dose reduction is required, but elderly patients and those receiving diuretics should be appropriately hydrated before dosing. The 5 mg infusion must run for at least 15 minutes. Dehydration and rapid infusion increase renal risk; unsupported dose reductions may compromise treatment without making unsafe administration acceptable.

Reference: Aclasta 5 mg solution for infusion SmPC: https://www.medicines.org.uk/emc/product/210/smpc