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Anti-SAE Dermatomyositis — SCE Rheumatology MCQ

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HardMyositisAnti-SAE DermatomyositisSCE Rheumatology

A 42-year-old woman with dermatomyositis has anti-SAE (anti-small ubiquitin-like modifier activating enzyme) antibody positivity. What clinical phenotype is associated with this antibody?

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Correct answer: DSkin-predominant disease that may evolve to include myositis later often with dysphagia and systemic features

The best answer is “Skin-predominant disease that may evolve to include myositis later often with dysphagia and systemic features”. Skin-predominant disease that may evolve to include myositis later often with dysphagia and systemic features is supported by the cited UK or directly applicable specialist authority and best matches the tested threshold, complication or monitoring principle. The remaining choices—“Inclusion body myositis, after specialist assessment, after specialist assessment, with clinical reassessment, within a rheumatology pathway”, “Necrotising myopathy, within a rheumatology pathway, with clinical reassessment, within a rheumatology pathway, after safety review”, “No clinical significance, after safety review, within a rheumatology pathway, after safety review, after specialist assessment”, “Severe rapidly progressive ILD, after safety review, after specialist assessment, with clinical reassessment”—are credible in related rheumatology presentations, but each addresses a different diagnosis, investigation, treatment sequence or complication and does not fit the decisive findings in this stem.

Reference: BSR guideline on idiopathic inflammatory myopathy: https://academic.oup.com/rheumatology/article/61/5/1760/6555980