SLE Criteria Weighting — SCE Rheumatology MCQ
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Correct answer: D — It prevents new ulcers but does not hasten healing of existing ulcers
Explanation lettering: E = shown as A · D = shown as B · A = shown as C · B = shown as D · C = shown as E
B is correct. The RAPIDS studies showed fewer new digital ulcers with bosentan, especially in patients with multiple ulcers, but no improvement in time to healing of existing ulcers. It is therefore a prevention strategy, not a substitute for wound care, infection assessment, analgesia, revascularisation review or other management of an established ulcer.
Reference: Bosentan 62.5 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/820/smpc